Cellular Biology Tuning Electrical Conduction Along Endothelial Tubes of Resistance Arteries Through Ca -Activated K Channels
نویسندگان
چکیده
Rationale: Electrical conduction through gap junction channels between endothelial cells of resistance vessels is integral to blood flow control. Small and intermediate-conductance Ca -activated K channels (SKCa/IKCa) initiate electrical signals in endothelial cells, but it is unknown whether SKCa/IKCa activation alters signal transmission along the endothelium. Objective: We tested the hypothesis that SKCa/IKCa activity regulates electrical conduction along the endothelium of resistance vessels. Methods and Results: Freshly isolated endothelial cell tubes (60 m wide; 1–3 mm long; cell length, 35 m)
منابع مشابه
Tuning electrical conduction along endothelial tubes of resistance arteries through Ca(2+)-activated K(+) channels.
RATIONALE Electrical conduction through gap junction channels between endothelial cells of resistance vessels is integral to blood flow control. Small and intermediate-conductance Ca(2+)-activated K(+) channels (SK(Ca)/IK(Ca)) initiate electrical signals in endothelial cells, but it is unknown whether SK(Ca)/IK(Ca) activation alters signal transmission along the endothelium. OBJECTIVE We test...
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